13-valent pneumococcal conjugate vaccine
What is pneumococcal infection?
Pneumococcal infection represents a wide range of diseases caused by the bacterium Streptococcus pneumoniae (or more commonly referred as pneumococcus). While pneumococcus is a common cause of mild illnesses such as sinus or middle ear infections, it may also cause severe or even life-threatening invasive pneumococcal diseases (IPD) such as bacteremic pneumonia, sepsis, and meningitis. The outcomes for IPD are usually more severe among young children and elderly persons.
Who should get pneumococcal vaccines?
SCVPD recommends high-risk individuals* aged 2 years or above to receive a single dose of 13-valent pneumococcal conjugate vaccine (PCV13), followed by a single dose of 23-valent pneumococcal polysaccharide vaccine (23vPPV) 1 year later. For those who have already received 23vPPV, a single dose of PCV13 should be administered 1 year after previous 23vPPV vaccination. For those who have already received PCV13, a single dose of 23vPPV should be administered 1 year after previous PCV13.
For elderly 65 years of age and older without high-risk conditions*, SCVPD recommends either a single dose of PCV13 or a single dose of 23vPPV.
*High-risk conditions include:
- History of invasive pneumococcal disease;
- Immunocompromised states:
- Asplenia, HIV /AIDS , primary immunodeficiency
- Immunodeficiencies related to malignancies and transplantation
- Immunodeficiencies related to use of immunosuppressive drugs / systemic steroid
- Chronic cardiac, pulmonary, liver or renal disease
- Diabetes mellitus or Cerebrospinal fluid leakage
Can pneumococcal vaccines be received together with seasonal influenza vaccine?
Yes. Both 23-valent pneumococcal polysaccharide vaccine (23vPPV) and pneumococcal conjugate vaccine (PCV) can be given together with other vaccines, including influenza vaccine, but they should be administered with a different syringe and at a different injection site.
What are the possible adverse reactions following pneumococcal conjugate vaccine (PCV) administration?
PCV has been demonstrated to be safe. Common adverse reactions include slight swelling and tenderness at the injection site shortly following injection but most resolve within two days. Some may experience mild fever, fatigue, headache, chills, or muscle pain. Severe pain or difficulty in moving the arm where the shot was given was very rare.
Who are not suitable to receive pneumococcal vaccines?
Severe allergic reaction following a prior dose of pneumococcal vaccine or to the vaccine component or any diphtheria toxoid-containing vaccine is a contraindication to further doses of vaccine.